Molecular-Genetic Mapping of Zebrafish Mutants with Variable Phenotypic Penetrance
نویسندگان
چکیده
منابع مشابه
Molecular-Genetic Mapping of Zebrafish Mutants with Variable Phenotypic Penetrance
Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitiv...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0026510